Introduction: The Energy Problem Nobody Talks About After 40
You wake up tired. Your afternoon slump hits like clockwork. You notice your hands and feet always seem cold — and your doctor keeps mentioning your blood pressure numbers at every visit.
Sound familiar? If you’re over 40, there’s a good chance these aren’t random complaints. They may share a common root: declining nitric oxide levels.
Nitric oxide is a molecule your body makes naturally, and it plays a critical role in keeping blood vessels relaxed, blood flow healthy, and energy levels up. The catch? Research shows production drops significantly as we age — and most people have never heard of it.
Advanced Bionutritionals CircO2 is a supplement designed specifically to address this problem. Unlike the typical capsule or tablet, it comes in a fast-dissolving lozenge format — and there’s real science behind why that delivery method might matter. Let’s take a close look.
What Is Advanced Bionutritionals Nitric Oxide (CircO2)?
CircO2 is a nitric oxide support supplement made by Advanced Bionutritionals. It’s formulated specifically for adults over 40 — the age range where nitric oxide levels tend to start declining noticeably.
The product’s main claim is that it can restore healthy nitric oxide levels within as little as 20 minutes. To achieve this, it uses a lozenge (not a pill) that dissolves on your tongue rather than going straight to your stomach.
The formula was developed in collaboration with Dr. Greg Eckel, a Naturopathic Physician with over 23 years of experience in integrative and regenerative medicine. He’s appeared on ABC, NBC, and FOX, and founded the Energy4Life Centers.
Key Ingredients: What’s Actually Inside CircO2?
Let’s get into what’s in the formula — and why each ingredient is there. The ingredient list is focused and sensible, with no unnecessary fillers that are common in lesser supplements.
Beet Root Powder
Rich in natural nitrates, beet root is well-studied for improving oxygen flow and stamina. It’s a go-to for endurance athletes for exactly this reason.
Hawthorn Berry
Used traditionally to support cardiovascular health for centuries. More recently, it’s been linked to improved nitric oxide absorption — helping your body use more of what it produces.
L-Citrulline
Unlike L-arginine (which loses potency during digestion), L-citrulline converts to nitric oxide more reliably — especially in adults over 45. It also supports memory and circulation.
Vitamin B12
Up to 30% of adults over 50 are deficient in B12 without realizing it. It supports energy metabolism, nerve function, and plays a role in nitric oxide production.
Vitamin C
Acts as a catalyst for nitric oxide synthesis and helps protect nitric oxide from oxidative breakdown — so your body holds onto it longer.
Magnesium
Supports blood vessel relaxation, heart rhythm regulation, and muscle recovery. Magnesium deficiency is surprisingly common in adults over 50.
A Note on L-Citrulline vs. L-Arginine
Many older nitric oxide supplements are built around L-arginine, but the evidence for it is shaky — especially for older adults. Studies suggest L-arginine loses a significant portion of its potency during digestion, and the body’s ability to convert it after age 45 declines noticeably.
L-citrulline takes a different metabolic pathway. It survives digestion better and is more reliably converted into nitric oxide. The decision to use L-citrulline instead of L-arginine is a meaningful, evidence-backed formulation choice.
Pros & Cons: An Honest Assessment
👍 Pros
- Lozenge delivery aligns with how nitric oxide production actually starts in the body
- Uses L-citrulline instead of the less effective L-arginine
- Ingredients backed by published research, not just marketing claims
- Formulated by a licensed naturopathic physician
- Includes complementary nutrients (B12, Magnesium, Vitamin C) not found in most NO supplements
- Comes with a 90-day money-back guarantee — even on empty boxes
- Free shipping on multi-box orders
👎 Cons
- Only available online — not sold in stores like CVS or Walmart
- Best value requires purchasing 3+ boxes at a time
- Not a quick fix — most users report noticing effects over days to weeks, not immediately
- Individual results will vary depending on diet and health status
- Lozenges may not suit everyone’s preference for supplement format
Are There Any Side Effects?
CircO2 is made with natural ingredients and is generally considered well-tolerated for most healthy adults. The formula avoids synthetic stimulants, so you won’t get the jitteriness or energy crashes associated with caffeine-based products.
That said, no supplement is completely without consideration. People on blood pressure medications should be mindful that ingredients like beet root and L-citrulline can have mild blood-pressure-lowering effects.
Bottom line: As with any supplement, it’s a good idea to have a quick conversation with your doctor before starting — especially if you take prescription medications or have an existing cardiovascular condition.
Conclusion: Should You Try CircO2?
If you’ve been dealing with low energy, sluggish circulation, or just a general sense that you’re not recovering the way you used to — and you’re looking for a natural approach rather than synthetic stimulants — CircO2 is one of the more thoughtfully formulated options out there.
The lozenge delivery system isn’t just a gimmick; it’s based on how nitric oxide production actually works in the body. And the ingredient choices — L-citrulline over L-arginine, hawthorn berry for absorption, and supporting nutrients like B12 and magnesium — show that this formula was built with older adults specifically in mind.
It won’t replace healthy lifestyle habits, and it’s not a miracle cure. But as a daily nutritional foundation for supporting circulation and energy after 40, it earns a solid recommendation. The 90-day guarantee makes it essentially risk-free to try.
Ready to Try CircO2 Risk-Free?
Advanced Bionutritionals only sells CircO2 through their official website — where you’ll find the best pricing and their full 90-day “down to the last lozenge” guarantee.
Ordering 3 boxes saves $15 and includes free shipping.
Check Official Price & Availability🔒 90-Day Money-Back Guarantee · Free Shipping on Multi-Box Orders · Official Website Only